Traf3ip2^tm1Sbn
Targeted Allele Detail

Summary

• Symbol: Traf3ip2^tm1Sbn
• Name: TRAF3 interacting protein 2; targeted mutation 1, Ulrich Siebenlist
• MGI ID: MGI:3831153
• Synonyms: CIKS^-
• Gene: Traf3ip2 Location: Chr10:39488930-39531303 bp, + strand Genetic Position: Chr10, 20.86 cM
• Alliance: Traf3ip2^tm1Sbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144320
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3.6 Kb BamHI fragment containing exon 2 was replaced with a neomycin selection cassette. Correct targeting was confirmed by Southern blotting. Analysis of mRNAs from homozygote B cells demonstrates exon 1 was spliced to exon 3. All potential ATG start codons upstream of exon 3 and located in the correct reading frame are followed by at least 2 stop codons prior to the start of exon 3. The first ATG present within the functional reading frame downstream of the start of exon 3 is located in exon 5, which could only generate a 157 amino acid long fragment of the 555 amino acid endogenous protein. For these reasons, a functional protein product was considered unlikely. (J:144320)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Traf3ip2 Mutation: 41 strains or lines available

References

• Original: J:144320 Claudio E, et al., The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol. 2009 Feb 1;182(3):1617-30
• All: 14 reference(s)