Dock3^tm1Dasc
Targeted Allele Detail

Summary

• Symbol: Dock3^tm1Dasc
• Name: dedicator of cyto-kinesis 3; targeted mutation 1, David Schubert
• MGI ID: MGI:3831156
• Synonyms: Moca^-
• Gene: Dock3 Location: Chr9:106770024-107109108 bp, - strand Genetic Position: Chr9, 57.98 cM
• Alliance: Dock3^tm1Dasc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144341
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 following the translation initiation site was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on brain, spinal cord, pituitary, and testis extracts. (J:144341)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dock3 Mutation: 97 strains or lines available

References

• Original: J:144341 Chen Q, et al., Loss of modifier of cell adhesion reveals a pathway leading to axonal degeneration. J Neurosci. 2009 Jan 7;29(1):118-30
• All: 3 reference(s)