Lig4^tm1Pmc
Targeted Allele Detail

Summary

• Symbol: Lig4^tm1Pmc
• Name: ligase IV, DNA, ATP-dependent; targeted mutation 1, Peter J McKinnon
• MGI ID: MGI:3831168
• Synonyms: Lig4^LoxP, Lig IV^loxP, pLig4^LoxP
• Gene: Lig4 Location: Chr8:10020020-10027680 bp, - strand Genetic Position: Chr8, 4.52 cM
• Alliance: Lig4^tm1Pmc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144172
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• The open reading frame was flanked with loxP sites. (J:144172)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Lig4^tm1Pmc

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lig4 Mutation: 46 strains or lines available

References

• Original: J:144172 Shull ER, et al., Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 2009 Jan 15;23(2):171-80
• All: 7 reference(s)