Tg(Pbsn-IGF1*)5305Ng
Transgene Detail

Summary

• Symbol: Tg(Pbsn-IGF1*)5305Ng
• Name: transgene insertion 5305, Norman M Greenberg
• MGI ID: MGI:3831172
• Synonyms: IGF-1^des, PB-Des, PB Des IGF-1, PB-IGF1^des1,3
• Transgene: Tg(Pbsn-IGF1*)5305Ng Location: unknown
• Alliance: Tg(Pbsn-IGF1*)5305Ng page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Pbsn-IGF1*)5305Ng expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IGF1 (3479)

  Igf1	(MGI:96432)

• Mutation details: A transgenic construct containing the human insulin-like growth factor 1 (somatomedin C) isoform, IGF-1des (that has a 3-amino acid deletion in the N terminus of the mature protein), under the control of the minimal -426/+28 rat probasin promoter, and carrying SV40 polyadenylation site sequences was injected into fertilized FVB/N mouse eggs. Three lines were generated (5299, 5305, and 6206). Founder line 5305 showed the highest expression and was characterized most thoroughly. (J:144539)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:144539 Kaplan-Lefko PJ, et al., Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene. 2008 May 1;27(20):2868-76
• All: 2 reference(s)