Nbn^tm3Jpt
Targeted Allele Detail

Summary

• Symbol: Nbn^tm3Jpt
• Name: nibrin; targeted mutation 3, John H J Petrini
• MGI ID: MGI:3831174
• Synonyms: Nbn^deltaBC
• Gene: Nbn Location: Chr4:15957925-15992589 bp, + strand Genetic Position: Chr4, 6.66 cM, cytoband A
• Alliance: Nbn^tm3Jpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144172
• Parent Cell Line: AC1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector used to create Nbn^tm1Jpt was used in embryonic stem cells containing Nbn^tm2.1Jpt to create an allele that coded for amino acids 221 to 727. The predicted protein lacks the FHA, BRCT and ATM-interacting domains. (J:144172)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nbn Mutation: 59 strains or lines available

References

• Original: J:144172 Shull ER, et al., Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 2009 Jan 15;23(2):171-80
• All: 1 reference(s)