Gprc6a^tm1Ldq
Targeted Allele Detail

Summary

• Symbol: Gprc6a^tm1Ldq
• Name: G protein-coupled receptor, family C, group 6, member A; targeted mutation 1, L Darryl Quarles
• MGI ID: MGI:3831176
• Synonyms: GPRC6A^-
• Gene: Gprc6a Location: Chr10:51490919-51507554 bp, - strand Genetic Position: Chr10, 25.66 cM
• Alliance: Gprc6a^tm1Ldq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144372
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed PGK-hygromycin cassette replaced exon 2. Absence of transcription was demonstrated by RT-PCR and Western blot analysis confirmed the absence of protein. (J:144372)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc6a Mutation: 67 strains or lines available

References

• Original: J:144372 Pi M, et al., GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome. PLoS One. 2008;3(12):e3858
• All: 7 reference(s)