Pten^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Pten^tm1Rdp
• Name: phosphatase and tensin homolog; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:3831201
• Synonyms: Pten^L, Pten^lox, Pten^lox5
• Gene: Pten Location: Chr19:32734977-32803560 bp, + strand Genetic Position: Chr19, 28.14 cM
• Alliance: Pten^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140704
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted upstream of exon 5 and an additional loxP site was inserted downstream of exon 5. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 5 floxed. (J:140704)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Pten^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pten Mutation: 88 strains or lines available

References

• Original: J:140704 Zheng H, et al., p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature. 2008 Oct 23;455(7216):1129-33
• All: 49 reference(s)