Kalrn^tm1.1Npl
Targeted Allele Detail

Summary

• Symbol: Kalrn^tm1.1Npl
• Name: kalirin, RhoGEF kinase; targeted mutation 1.1, Neuropeptide Laboratory
• MGI ID: MGI:3831292
• Synonyms: Kal7^KO, Kalrn^tm1.1Riem
• Gene: Kalrn Location: Chr16:33789443-34393647 bp, - strand Genetic Position: Chr16, 24.27 cM
• Alliance: Kalrn^tm1.1Npl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:142364
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove the exon specific for isoform 7. The absence of protein expression of Kalrn7 and deltaKalrn7 was confirmed by western blot analysis of cerebral cortex extracts. (J:142364)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kalrn Mutation: 171 strains or lines available

References

• Original: J:142364 Ma XM, et al., Kalirin-7 is required for synaptic structure and function. J Neurosci. 2008 Nov 19;28(47):12368-82
• All: 8 reference(s)