Gpr83^tm1.1Fpow
Targeted Allele Detail

Summary

• Symbol: Gpr83^tm1.1Fpow
• Name: G protein-coupled receptor 83; targeted mutation 1.1, Fiona Powrie
• MGI ID: MGI:3831302
• Gene: Gpr83 Location: Chr9:14771506-14782085 bp, + strand Genetic Position: Chr9, 4.4 cM, cytoband A2-A3
• Alliance: Gpr83^tm1.1Fpow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144445
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Germ line, cre-mediated recombination was used to remove exons 2 and 3. The absence of transcripts expression exons 2 and 3 was confirmed by RT-PCR on extracts from CD4+CD25- and CD4+CD25+ T cells. (J:144445)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr83 Mutation: 26 strains or lines available

References

• Original: J:144445 Toms C, et al., Gpr83 expression is not required for the maintenance of intestinal immune homeostasis and regulation of T-cell-dependent colitis. Immunology. 2008 Nov;125(3):302-12
• All: 3 reference(s)