Tlr6^m4Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tlr6^m4Btlr
• Name: toll-like receptor 6; mutation 4, Bruce Beutler
• MGI ID: MGI:3831306
• Synonyms: m2sd3, MALP-2 specific defect 3
• Gene: Tlr6 Location: Chr5:65109374-65117440 bp, - strand Genetic Position: Chr5, 33.54 cM
• Alliance: Tlr6^m4Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was discovered in a TLR Signaling Screen of G3 progeny of an ENU mutagenized male mouse. The mutation comprises a T to C transition at nucleotide position 1454 of the gene (Genbank: NM_011604) that results in replacement of isoleucine by threonine at amino acid position 441 of the protein (I441T). (J:144168)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tlr6 Mutation: 50 strains or lines available

References

• Original: J:144168 Siggs OM, et al., Record for "m2sd3", updated February 2, 2009. MGI Direct Data Submission. 2009
• All: 1 reference(s)