Sac3d1^tm1Hnaka
Targeted Allele Detail

Summary

• Symbol: Sac3d1^tm1Hnaka
• Name: SAC3 domain containing 1; targeted mutation 1, Hideaki Nakajima
• MGI ID: MGI:3831538
• Synonyms: SHD1^-
• Gene: Sac3d1 Location: Chr19:6166030-6168680 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Sac3d1^tm1Hnaka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144601
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A SpeI-NotI fragment containing the proximal promoter and the upstream-portion of exon 1 was replaced with neomycin resistance gene. Correct targeting was confirmed by Southern blotting. Gene inactivation was confirmed by a failure to detect protein product in immunoblot analysis of thymocyte nuclear extracts collected from homozgytoes. (J:144601)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sac3d1 Mutation: 12 strains or lines available

References

• Original: J:144601 Nakajima H, et al., SHD1 is a novel cytokine-inducible, negative feedback regulator of STAT5-dependent transcription. Blood. 2009 Jan 29;113(5):1027-36
• All: 1 reference(s)