Dyrk3^tm1Dowo
Targeted Allele Detail

Summary

• Symbol: Dyrk3^tm1Dowo
• Name: dual-specificity tyrosine phosphorylation regulated kinase 3; targeted mutation 1, Don M Wojchowski
• MGI ID: MGI:3831552
• Gene: Dyrk3 Location: Chr1:131056178-131065991 bp, - strand Genetic Position: Chr1, 56.9 cM
• Alliance: Dyrk3^tm1Dowo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144586
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a floxed neo cassette. This exon encodes the catalytic domain and a unique C-terminal region. Germ line, cre-mediated recombination was used to remove the neo cassette. The absence of transcript expression was confirmed by RT-PCR on extracts from early and late erythroblasts. (J:144586)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk3 Mutation: 35 strains or lines available

References

• Original: J:144586 Bogacheva O, et al., DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. J Biol Chem. 2008 Dec 26;283(52):36665-75
• All: 1 reference(s)