Slc26a6^tm1Smua
Targeted Allele Detail

Summary

• Symbol: Slc26a6^tm1Smua
• Name: solute carrier family 26, member 6; targeted mutation 1, Shmuel Muallem
• MGI ID: MGI:3831563
• Gene: Slc26a6 Location: Chr9:108731239-108742117 bp, + strand Genetic Position: Chr9, 59.63 cM, cytoband F2
• Alliance: Slc26a6^tm1Smua page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144457
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A fragment including exons 7 - 9 was replaced with a neo cassette via homologous recombination. (J:144457)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc26a6 Mutation: 32 strains or lines available

References

• Original: J:144457 Wang Y, et al., Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis. EMBO J. 2006 Nov 1;25(21):5049-57
• All: 5 reference(s)