Tph1^tm2Lex
Targeted Allele Detail

Summary

• Symbol: Tph1^tm2Lex
• Name: tryptophan hydroxylase 1; targeted mutation 2, Lexicon Pharmaceuticals
• MGI ID: MGI:3831653
• Gene: Tph1 Location: Chr7:46294065-46321961 bp, - strand Genetic Position: Chr7, 30.43 cM
• Alliance: Tph1^tm2Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144582
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2 was replaced with a neo cassette. (J:144582)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tph1 Mutation: 41 strains or lines available

References

• Original: J:144582 Savelieva KV, et al., Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008;3(10):e3301
• All: 2 reference(s)