Tph2^tm1Lex
Targeted Allele Detail

Summary

• Symbol: Tph2^tm1Lex
• Name: tryptophan hydroxylase 2; targeted mutation 1, Lexicon Genetics
• MGI ID: MGI:3831654
• Gene: Tph2 Location: Chr10:114914546-115020927 bp, - strand Genetic Position: Chr10, 63.51 cM
• Alliance: Tph2^tm1Lex page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144582
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with a neo cassette. (J:144582)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tph2 Mutation: 43 strains or lines available

References

• Original: J:144582 Savelieva KV, et al., Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PLoS One. 2008;3(10):e3301
• All: 4 reference(s)