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Tg(Gcg-TGFB1)1Itak
Transgene Detail
Summary
Symbol: Tg(Gcg-TGFB1)1Itak
Name: transgene insertion 1, Mitsuo Itakura
MGI ID: MGI:3831665
Transgene: Tg(Gcg-TGFB1)1Itak  Location: unknown  
Alliance: Tg(Gcg-TGFB1)1Itak page
Transgene
origin
Strain of Origin:  NOD
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Gcg-TGFB1)1Itak expresses 1 gene
 
Mutation detailsThe cDNA for porcine TGFB1 was modified so that the codons for amino acid residues 223 and 225 that normally encode cysteine now encode serine. This cDNA was place under the control of the rat glucagon promoter. (J:109797)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:109797 Moritani M, et al., Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic paracrine TGF-beta1. J Clin Invest. 1998 Aug 1;102(3):499-506
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory