Trafd1^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Trafd1^tm1Ayos
• Name: TRAF type zinc finger domain containing 1; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:3831676
• Synonyms: FLN29^-
• Gene: Trafd1 Location: Chr5:121509788-121523695 bp, - strand Genetic Position: Chr5, 61.78 cM
• Alliance: Trafd1^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144594
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis. (J:144594)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Trafd1 Mutation: 29 strains or lines available

References

• Original: J:144594 Sanada T, et al., FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. J Biol Chem. 2008 Dec 5;283(49):33858-64
• All: 1 reference(s)