F2^tm1Jld
Targeted Allele Detail

Summary

• Symbol: F2^tm1Jld
• Name: coagulation factor II; targeted mutation 1, Jay L Degen
• MGI ID: MGI:3831686
• Synonyms: FII^lox
• Gene: F2 Location: Chr2:91455665-91466759 bp, - strand Genetic Position: Chr2, 50.63 cM
• Alliance: F2^tm1Jld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144572
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Duplication, Insertion, Intragenic deletion
• F2^tm1Jld involves 1 genes/genome features (F2) View all
• Mutation details: A loxP site was inserted upstream of exon 3, and exons 5 through 6 were replaced with a cDNA encoding exons 5 through 14 followed by a human GH polyadenylation sequence, an HPRT minigene and loxP site. Exons 10 through 14 are duplicated in the gene but not the transcript. (J:144572)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F2 Mutation: 36 strains or lines available

References

• Original: J:144572 Mullins ES, et al., Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 2009 Jan 15;113(3):696-704
• All: 6 reference(s)