Hdac3^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac3^tm1.1Eno
• Name: histone deacetylase 3; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3831693
• Synonyms: Hdac3^loxP
• Gene: Hdac3 Location: Chr18:38070024-38088073 bp, - strand Genetic Position: Chr18, 19.81 cM, cytoband B3
• Alliance: Hdac3^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144604
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 10 and an frt flanked neomycin selection as well as a second loxP site were placed in intron 14. The neomycin cassette was subsequently removed by crossing to FLPe transgenic mice which leaves exons 11-14 flanked by loxP. (J:144604)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac3 Mutation: 33 strains or lines available

References

• Original: J:144604 Montgomery RL, et al., Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. J Clin Invest. 2008 Nov;118(11):3588-97
• All: 14 reference(s)