Cnr1^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Cnr1^tm1Dgen
• Name: cannabinoid receptor 1; targeted mutation 1, Deltagen
• MGI ID: MGI:3831701
• Synonyms: CB1^-
• Gene: Cnr1 Location: Chr4:33924593-33948831 bp, + strand Genetic Position: Chr4, 16.28 cM
• Alliance: Cnr1^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144774
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: 11.4 kb of the open reading frame was replaced with a cassette containing an IRES-lacZ and neo gene. The absence of protein expression was confirmed by the lack of radio-labelled CP55,940 binding in the brain. (J:144774)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cnr1 Mutation: 42 strains or lines available

References

• Original: J:144774 Ibrahim MM, et al., Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: pain inhibition by receptors not present in the CNS. Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10529-33
• All: 8 reference(s)