Myoz1^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Myoz1^tm1Eno
• Name: myozenin 1; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3831744
• Gene: Myoz1 Location: Chr14:20699175-20706608 bp, - strand Genetic Position: Chr14, 11.53 cM
• Alliance: Myoz1^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144597
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a lacZ reporter and a PGK-neomycin selection cassette. Western blot analysis confirmed the absence of gene expression in the gastrocnemius muscle. (J:144597)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myoz1 Mutation: 25 strains or lines available

References

• Original: J:144597 Frey N, et al., Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest. 2008 Nov;118(11):3598-608
• All: 1 reference(s)