mt-Nd2^m1
Spontaneous Allele Detail

Summary

• Symbol: mt-Nd2^m1
• Name: mitochondrially encoded NADH dehydrogenase 2; mutation 1
• MGI ID: MGI:3831873
• Synonyms: mt-Nd2(a)
• Gene: mt-Nd2 Location: ChrMT:3914-4951 bp, + strand Genetic Position: ChrMT, Syntenic
• Alliance: mt-Nd2^m1 page

Mutation origin

• Strain of Origin: ALR/Lt

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A C-to-A mutation at postition 4739 of the mitochondrial DNA results in a leucine (CTA codon) to methionine (miochondrial codon ATA) substitution at amino acid residue 276 (p.L276M) in the mitochondrial NADH dehydrogenase 2 gene. (J:97969)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any mt-Nd2 Mutation: 0 strains or lines available

Notes

ALR/Lt maternal genome differentially suppresses development of spontaneous type 1 diabetes in BC1 females produced by reciprocal outcross of ALR/Lt to NOD/Lt.

References

• Original: J:97969 Mathews CE, et al., mt-Nd2 Allele of the ALR/Lt mouse confers resistance against both chemically induced and autoimmune diabetes. Diabetologia. 2005 Feb;48(2):261-7
• All: 4 reference(s)