Plxna1^tm1Tmj
Targeted Allele Detail

Summary

• Symbol: Plxna1^tm1Tmj
• Name: plexin A1; targeted mutation 1, Thomas M Jessell
• MGI ID: MGI:3831874
• Gene: Plxna1 Location: Chr6:89293295-89339595 bp, - strand Genetic Position: Chr6, 39.91 cM, cytoband E2
• Alliance: Plxna1^tm1Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144660
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2, beginning downstream of the translation initiation site, and all of exon 3 were replaced with a floxed neo cassette and a farnesylated EGFP. The absence of protein expression was confirmed by immunohistochemistry. (J:144660)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plxna1 Mutation: 75 strains or lines available

References

• Original: J:144660 Yoshida Y, et al., PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. Neuron. 2006 Dec 7;52(5):775-88
• All: 16 reference(s)