Pot1b^tm1.1Schg
Targeted Allele Detail

Summary

• Symbol: Pot1b^tm1.1Schg
• Name: protection of telomeres 1B; targeted mutation 1.1, Sandy Chang
• MGI ID: MGI:3831881
• Synonyms: Pot1b^delta
• Gene: Pot1b Location: Chr17:55958951-56019628 bp, - strand Genetic Position: Chr17, 28.93 cM, cytoband D
• Alliance: Pot1b^tm1.1Schg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144553
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination of Pot1b^tm1Schg removed exons 3 and 4. RT-PCR confirmed the absence of mRNA transcripts in homozygous MEFs. (J:144553)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pot1b Mutation: 38 strains or lines available

References

• Original: J:144553 He H, et al., Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita. Mol Cell Biol. 2009 Jan;29(1):229-40
• All: 5 reference(s)