Itga9^tm2Des
Targeted Allele Detail

Summary

• Symbol: Itga9^tm2Des
• Name: integrin alpha 9; targeted mutation 2, Dean Sheppard
• MGI ID: MGI:3832228
• Synonyms: alpha9^fl, Itga9^lx, Itga9^tm1Vdw
• Gene: Itga9 Location: Chr9:118435777-118730071 bp, + strand Genetic Position: Chr9, 70.32 cM
• Alliance: Itga9^tm2Des page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144854
• Parent Cell Line: RF8 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted in intron 7 at the beginning of exon 8. An FRT flanked neomycin selection cassette followed by a second loxP site was also inserted 3' to exon 8. The neomycin selection cassette was excised by crossing to FLPe expressing transgenic mice. (J:144854)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itga9 Mutation: 60 strains or lines available

References

• Original: J:144854 Singh P, et al., Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol. 2009 Jan;129(1):217-28
• All: 10 reference(s)