Tg(Scgb1a1-Il13)2Eli
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-Il13)2Eli
• Name: transgene insertion 2, Jack A Elias
• MGI ID: MGI:3832264
• Synonyms: cIl-13, Tg(Cc10-Il13)
• Transgene: Tg(Scgb1a1-Il13)2Eli Location: unknown
• Alliance: Tg(Scgb1a1-Il13)2Eli page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Scgb1a1-Il13)2Eli expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il13 (MGI:96541)

• Mutation details: Expression of a mouse Il13 cDNA was placed under the control of the rat Scgb1a1 promoter. Human intronic growth hormone and polyadenylation sequence were place 3' to the mouse Il13 cDNA sequence. Two lines were described with essentially similar except that line 2 expressed more and displayed a more intense phenotype. (J:53612)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:53612 Zhu Z, et al., Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999 Mar;103(6):779-88
• All: 25 reference(s)