Slc6a3^tm2(tTA)Xz
Targeted Allele Detail

Summary

• Symbol: Slc6a3^tm2(tTA)Xz
• Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 2, Xiaoxi Zhuang
• MGI ID: MGI:3832286
• Synonyms: DAT-tTA
• Gene: Slc6a3 Location: Chr13:73684866-73726791 bp, + strand Genetic Position: Chr13, 40.1 cM
• Alliance: Slc6a3^tm2(tTA)Xz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144671
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Transactivator)
• Mutation: Insertion
• Mutation details: A tetracycline responsive transactivator and a floxed neo cassette were inserted into the 5' untranslated region. Germ line, cre-mediated recombination was used to remove the neo cassette. Expression is limited in dopaminergic neurons. (J:144671)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a3 Mutation: 66 strains or lines available

References

• Original: J:144671 Cagniard B, et al., Dopamine scales performance in the absence of new learning. Neuron. 2006 Sep 7;51(5):541-7
• All: 5 reference(s)