T(Tp(1E2.1);8B1.2)2Lub
Spontaneous Allele Detail

Summary

• Symbol: T(Tp(1E2.1);8B1.2)2Lub
• Name: transposition within a translocation 2, Medizinische Hochschule Lubeck; transposition within a translocation 2, Medizinische Hochschule Lubeck
• MGI ID: MGI:3832323
• Gene: T(Tp(1E2.1);8B1.2)2Lub Location: unknown Genetic Position: Chr8, Syntenic

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutations: Other, Translocation
• Mutation details: Position 33,249,449 of chromosome 8 is fused to position 114,385,410 of chromosome 1. There is also a transposition of the region between position 101,775,869 and position 114,385,390 to after position 116,939,662. This rearrangement results in the loss of 19 bp in the 114.4 Mb region and the loss of 4 bp in the 116.9 Mb region. The breakpoint in the 101.7 Mb region falls in the first intron of Cntnap5b. No known genes are located in or around any of the other breakpoints. RT-PCR confirms the absence of Cntnap5b expression in brains from homozygous mice. (J:144618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any T(Tp(1E2.1);8B1.2)2Lub Mutation: 0 strains or lines available

References

• Original: J:144618 Weichenhan D, et al., A mouse translocation associated with Caspr5-2 disruption and perinatal lethality. Mamm Genome. 2008 Dec;19(10-12):675-86
• All: 1 reference(s)