Slc6a1^tm1Mlit
Targeted Allele Detail

Summary

• Symbol: Slc6a1^tm1Mlit
• Name: solute carrier family 6 (neurotransmitter transporter, GABA), member 1; targeted mutation 1, Jian Fei
• MGI ID: MGI:3832387
• Synonyms: GAT1^-, Slc6a1^tm1Fei, Slc6a1^tm1Nfms
• Gene: Slc6a1 Location: Chr6:114259735-114294491 bp, + strand Genetic Position: Chr6, 53.05 cM, cytoband E3
• Alliance: Slc6a1^tm1Mlit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144919
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neomycin cassette. Immunoblot analysis of brain extracts demonstrated that heterozygotes had one-third the expression of protein of wild-types and that homozygotes had no expression of the protein. (J:144919)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc6a1 Mutation: 51 strains or lines available

References

• Original: J:144919 Cai YQ, et al., Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res. 2006 Aug 1;84(2):255-67
• All: 13 reference(s)