Ldb3^tm4Chen
Targeted Allele Detail

Summary

• Symbol: Ldb3^tm4Chen
• Name: LIM domain binding 3; targeted mutation 4, Ju Chen
• MGI ID: MGI:3832388
• Synonyms: Cypher^f
• Gene: Ldb3 Location: Chr14:34248560-34310639 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Ldb3^tm4Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144739
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1 was flanked with loxP sites and an frt flanked neo cassette was inserted after the second loxP site via homologous recombination. The neo cassette was then removed by Flp mediated recombination. (J:144739)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldb3 Mutation: 46 strains or lines available

References

• Original: J:144739 Zheng M, et al., Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death. Hum Mol Genet. 2009 Feb 15;18(4):701-13
• All: 2 reference(s)