Prlh^tm1Taon
Targeted Allele Detail

Summary

• Symbol: Prlh^tm1Taon
• Name: prolactin releasing hormone; targeted mutation 1, Tatsushi Onaka
• MGI ID: MGI:3832409
• Gene: Prlh Location: Chr1:90880830-90881749 bp, + strand Genetic Position: Chr1, 45.81 cM
• Alliance: Prlh^tm1Taon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144729
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A 2 kb fragment including both exons 1 and 2 was replaced with a neo cassette via homologous recombination. RT-PCR and radioimmunoassay confirm the absence of RNA and protein expression in the hypothalamus and medulla oblongata of homozygous mice. (J:144729)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prlh Mutation: 7 strains or lines available

References

• Original: J:144729 Takayanagi Y, et al., Endogenous prolactin-releasing peptide regulates food intake in rodents. J Clin Invest. 2008 Dec;118(12):4014-24
• All: 2 reference(s)