Rad50^tm3Jpt
Targeted Allele Detail

Summary

• Symbol: Rad50^tm3Jpt
• Name: RAD50 double strand break repair protein; targeted mutation 3, John H J Petrini
• MGI ID: MGI:3832533
• Synonyms: Rad50^ind
• Gene: Rad50 Location: Chr11:53540346-53598146 bp, - strand Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
• Alliance: Rad50^tm3Jpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144766
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A puromycin resistance cassette with a 5' loxP site was inserted upstream of exon 1, and an additional loxP site was inserted downstream of exon 2. (J:144766)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rad50 Mutation: 53 strains or lines available

References

• Original: J:144766 Adelman CA, et al., Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol Cell Biol. 2009 Jan;29(2):483-92
• All: 3 reference(s)