Casp12^tm1Dwni
Targeted Allele Detail

Summary

• Symbol: Casp12^tm1Dwni
• Name: caspase 12; targeted mutation 1, Donald W Nicholson
• MGI ID: MGI:3832547
• Gene: Casp12 Location: Chr9:5345430-5373032 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1
• Alliance: Casp12^tm1Dwni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144912
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/SvImJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A segment of exon 2 was targeted for replacement by a cassette consisting of the -galactosidase gene and the neomycin resistance gene, shifting the downstream sequence out of reading frame. Gene inactivation was confirmed by immunoblot analysis of protein extracts obtained from intestinal epithelial cells. Expression of the neighboring caspase genes Casp1 and Casp4 were unaffected in these mice. (J:144912)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp12 Mutation: 32 strains or lines available

References

• Original: J:144912 Saleh M, et al., Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature. 2006 Apr 20;440(7087):1064-8
• All: 6 reference(s)