Fktn^tm3(FKTN)Ttd
Targeted Allele Detail

Summary

• Symbol: Fktn^tm3(FKTN)Ttd
• Name: fukutin; targeted mutation 3, Tatsushi Toda
• MGI ID: MGI:3832562
• Synonyms: Ftkn^Hn
• Gene: Fktn Location: Chr4:53713745-53765785 bp, + strand Genetic Position: Chr4, 28.74 cM
• Alliance: Fktn^tm3(FKTN)Ttd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144746
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 10 was removed from the locus via Cre mediated expression following the insertion of lox71 and loxP sites. Wild-type human FKTN exon 10 cDNA was inserted into the locus between lox66 and loxP sites of the targeting construct. (J:144746)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fktn Mutation: 44 strains or lines available

References

• Original: J:144746 Kanagawa M, et al., Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum Mol Genet. 2009 Feb 15;18(4):621-31
• All: 2 reference(s)