Tg(Amhr2-Pik3ca*,-GFP)#Lzh
Transgene Detail

Summary

• Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh
• Name: transgene insertion, Lin Zhang
• MGI ID: MGI:3832594
• Synonyms: PIK3CA-Tg
• Transgene: Tg(Amhr2-Pik3ca*,-GFP)#Lzh Location: unknown
• Alliance: Tg(Amhr2-Pik3ca*,-GFP)#Lzh page

Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 females exhibit ovarian surface epithelium hyperplasia

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Amhr2-Pik3ca*,-GFP)#Lzh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pik3ca (MGI:1206581)

• Mutation details: This transgene consists of the mouse Amhr2 promoter driving expression of a constitutively active form of mouse Pik3ca and, following an IRES, GFP. The constitutively active form of Pik3ca was created by the addition of the avian src myristoylation sequence (MGSSKSKPK) to the N terminus of Pik3ca. Twelve founders were generated. This record represents pooled data from multiple founder lines. (J:144834)

The construct to generate Tg(Amhr2-Pik3ca*,-GFP)#Lzh/0 mice

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144834 Liang S, et al., Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation. PLoS One. 2009;4(1):e4295
• All: 1 reference(s)