Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3.1, Ari Waisman
• MGI ID: MGI:3832630
• Synonyms: Del-IL17A^ind
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai} page

Granulocytosis and anemia in Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai}/Gt(ROSA)26Sor⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144710
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il17a (MGI:107364)

• Mutation details: Germ line, cre-mediated recombination was used to remove the STOP cassette from the Gt(ROSA)26Sor^tm3Awai allele and allow for expression of IL-17A and EGFP regulated by a CAG promoter. (J:144710)

Generation of the Gt(ROSA)26Sor^{tm3(CAG-Il17a)Awai} and Gt(ROSA)26Sor^{tm3.1(CAG-Il17a)Awai} alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 993 strains or lines available

References

• Original: J:144710 Haak S, et al., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009 Jan;119(1):61-9
• All: 1 reference(s)