Senp2^tm1Whsu
Targeted Allele Detail

Summary

• Symbol: Senp2^tm1Whsu
• Name: SUMO/sentrin specific peptidase 2; targeted mutation 1, Wei Hsu
• MGI ID: MGI:3832730
• Synonyms: SENP2^lacZ
• Gene: Senp2 Location: Chr16:21828234-21868019 bp, + strand Genetic Position: Chr16, 12.98 cM, cytoband B1
• Alliance: Senp2^tm1Whsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144707
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-galactosidase gene was fused in-frame to exon 2 and exons 3 through 5 were deleted. A floxed neomycin selection cassette was included for targeting purposes and then subsequently removed by crossing founder mice with Zp3-cre transgenic mice. LacZ transcript but not endogenous transcript was detected by RT-PCR analysis of E10.5 embryos. (J:144707)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Senp2 Mutation: 51 strains or lines available

References

• Original: J:144707 Chiu SY, et al., SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol. 2008 Dec 16;6(12):e310
• All: 4 reference(s)