Tg(Ela2a-Prss1*,-GFP)1Dbs
Transgene Detail

Summary

• Symbol: Tg(Ela2a-Prss1*,-GFP)1Dbs
• Name: transgene insertion 1, Dafna Bar-Sagi
• MGI ID: MGI:3832840
• Synonyms: R122H_mPRSS1
• Transgene: Tg(Ela2a-Prss1*,-GFP)1Dbs Location: unknown
• Alliance: Tg(Ela2a-Prss1*,-GFP)1Dbs page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ela2a-Prss1*,-GFP)1Dbs expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Prss1 (MGI:98839)

• Mutation details: The rat promoter was used to drive acinar cell-specific expression of a flag-tagged cDNA with nucleotide substitutions that result in the amino acid substitution of histidine for arginine at position 122 (R122H) and an IRES-GFP reporter. Three lines were made with copy numbers of the transgene ranging from ten (in two of three lines) to low numbers (in one line). No line numbers were given. (J:144663)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144663 Archer H, et al., A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology. 2006 Dec;131(6):1844-55
• All: 1 reference(s)