Uhmk1^tm1Enbl
Targeted Allele Detail

Summary

• Symbol: Uhmk1^tm1Enbl
• Name: U2AF homology motif (UHM) kinase 1; targeted mutation 1, Elizabeth G Nabel
• MGI ID: MGI:3832867
• Synonyms: KIS^-
• Gene: Uhmk1 Location: Chr1:170020989-170042966 bp, - strand Genetic Position: Chr1, 76.84 cM, cytoband H2
• Alliance: Uhmk1^tm1Enbl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144737
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1, encoding the kinase activity domain, was replaced by a neomycin cassette in reverse orientation. Lack of expression was confirmed by both Northern and Western blot analysis. (J:144737)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uhmk1 Mutation: 26 strains or lines available

References

• Original: J:144737 Langenickel TH, et al., KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. J Clin Invest. 2008 Dec;118(12):3848-59
• All: 2 reference(s)