Mssq8^C57BL/6JJcl
QTL Variant Detail

Summary

• QTL variant: Mssq8^C57BL/6JJcl
• Name: mandible size and shape QTL 8; C57BL/6JJcl
• MGI ID: MGI:3832890
• QTL: Mssq8 Location: unknown Genetic Position: Chr8, Syntenic

Variant origin

• Strain of Specimen: C57BL/6JJcl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased values for principal component assessment of mandible size compared to KK/TaJcl. (J:143893)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:143893

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A^y/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A^y/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A^y/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A^y allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq8 (mandible size and shape QTL 8) on mouse Chromosome 8 is linked to principal component 3 at D8Mit58 (1 cM; LOD=5.1) in the a/a F2 population and at D8Mit281 (11 cM; LOD=5.7) in the combined F2 population. C57BL/6JJcl-derived alleles at Mssq8 confer increased values for PC3 mandible measurements. Principal component 3 values also displayed suggestive linkage to a locus at 30 cM near D8Mit205 (LOD=3.1).

References

• Original: J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
• All: 1 reference(s)