Mssq17^C57BL/6JJcl
QTL Variant Detail

Summary

• QTL variant: Mssq17^C57BL/6JJcl
• Name: mandible size and shape QTL 17; C57BL/6JJcl
• MGI ID: MGI:3832926
• QTL: Mssq17 Location: unknown Genetic Position: Chr10, Syntenic

Variant origin

• Strain of Specimen: C57BL/6JJcl

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: Homozygous C57BL/6JJcl alleles at Mssq17 in conjunction with heterozygous C57BL/6JJcl and KK/TaJcl alleles at Mssq7 confer increased mandible size. (J:143893)

Notes

Mssq17 interacts with Mssq7 on chromosome 5.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:143893

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A^y/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A^y/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A^y/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A^y allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq17 (mandible size and shape QTL 17) was identified at 25.5 cM on chromosome 10 near D10Mit184. This locus interacts with Mssq7 on chromosome 5. Homozygosity for C57BL/6JJcl-derived alleles at Mssq17 in conjunction with heterozygous alleles at Mssq7 confer significantly increased mandible size. This interaction is statistically significant with LOD=4.8.

References

• Original: J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
• All: 1 reference(s)