Mssq18^KK/TaJcl
QTL Variant Detail

Summary

• QTL variant: Mssq18^KK/TaJcl
• Name: mandible size and shape QTL 18; KK/TaJcl
• MGI ID: MGI:3832947
• QTL: Mssq18 Location: unknown Genetic Position: Chr14, Syntenic

Variant origin

• Strain of Specimen: KK/TaJcl

Variant description

• Allele Type: QTL

Notes

Mssq18 interacts with Mssq6 on chromosome 6. Homozygosity for KK- or C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous C57BL/6JJcl-derived alleles at Mssq6 confer decreased mandible size. Heterozygosity at both Mssq6 and Mssq18 significantly increases mandible size.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:143893

Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A^y/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A^y/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A^y/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A^y allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.

Mssq18 (mandible size and shape QTL 18) at 10 cM on mouse Chromosome 14 was identified as an interacting locus with Mssq6 on chromosome 6. Mssq18 maps near D14Mit44. Homozygosity for KK- or C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous C57BL/6JJcl-derived alleles at Mssq6 confer decreased mandible size. Heterozygosity at both Mssq6 and Mssq18 significantly increases mandible size. This interaction is statistically significant (LOD=3.7).

Mssq18 also interacts with Mssq19 on chromosome 16. Homozygous C57BL/6JJcl-derived alleles at Mssq18 in conjunction with homozygous KK-derived alleles at Mssq19 confers significantly increased mandible size measurements. This interaction is statistically significant (LOD=6.7).

References

• Original: J:143893 Suto J, Identification of multiple quantitative trait loci affecting the size and shape of the mandible in mice. Mamm Genome. 2009 Jan;20(1):1-13
• All: 1 reference(s)