Tg(CMV-TOR1A*)2Nush
Transgene Detail

Summary

• Symbol: Tg(CMV-TOR1A*)2Nush
• Name: transgene insertion 2, Nutan Sharma
• MGI ID: MGI:3832953
• Synonyms: hMT2
• Transgene: Tg(CMV-TOR1A*)2Nush Location: unknown
• Alliance: Tg(CMV-TOR1A*)2Nush page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-TOR1A*)2Nush expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TOR1A (1861)

  Tor1a

  (MGI:1353568)

• Mutation details: The promoter was used to drive ubiquitous expression of a human cDNA containing a 3 bp deletion (delta GAG) identified in patients with DYT1 dystonia. Two lines were created (hMT1 and hMT2) with a 2-fold and 1.2-fold increase in expression levels, respectively. (J:98716)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:98716 Sharma N, et al., Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005 Jun 1;25(22):5351-5
• All: 4 reference(s)