Tg(GH1-cre)1Sac
Transgene Detail

Summary

• Symbol: Tg(GH1-cre)1Sac
• Name: transgene insertion 1, Sally A Camper
• MGI ID: MGI:3833232
• Synonyms: Tg(Gh-cre)^SAC1
• Transgene: Tg(GH1-cre)1Sac Location: unknown
• Alliance: Tg(GH1-cre)1Sac page

Transgene origin

• Strain of Origin: (C57BL/6J x SJL/J)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(GH1-cre)1Sac expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  GH1 (2688)

  Gh	(MGI:95707)

• Mutation details: The human growth hormone locus control region (-16.2 to -14.6 kb relative to the GH1 promoter) was fused to 1.77 kb of rat Gh1 promoter to drive expression of a cre recombinase cassette in the pituitary gland. About 30-50 copies of the transgene construct inserted into the genome after injection into zygotes. When crossed with cre-reporter strains, cre expression was observed in the pituitary somatotropes, with limited expression in lactotropes, and no detectable expression in other pituitary cell types. Cre expression was also detected in the skin of embryonic forelimbs and trunk, and in adult testis, ovary, and kidney. (J:144723)

Structure of the Tg(GH1-cre)1Sac transgene

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	GH1 (human) Summary of all recombinase alleles driven by GH1. Comparative matrix view of recombinase activities Alliance human GH1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:144723 Nasonkin IO, et al., Cre-mediated recombination in pituitary somatotropes. Genesis. 2009 Jan;47(1):55-60
• All: 1 reference(s)