Tg(Thy1-SERPINI1)183Icka
Transgene Detail

Summary

• Symbol: Tg(Thy1-SERPINI1)183Icka
• Name: transgene insertion 183, Ichiro Kato
• MGI ID: MGI:3833391
• Transgene: Tg(Thy1-SERPINI1)183Icka Location: unknown
• Alliance: Tg(Thy1-SERPINI1)183Icka page

Transgene origin

• Strain of Origin: (C57BL x DBA)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-SERPINI1)183Icka expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SERPINI1 (5274)

  Serpini1

  (MGI:1194506)

• Mutation details: The promoter was used to drive neuron-specific expression of the human cDNA. Three lines were created (183, 819, and 824), and line 183 was selected as the representative line. (J:144649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:144649 Takasawa A, et al., Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J Biol Chem. 2008 Dec 19;283(51):35606-13
• All: 1 reference(s)