Plcg2^al
Spontaneous Allele Detail

Summary

• Symbol: Plcg2^al
• Name: phospholipase C, gamma 2; abnormal lymphatics
• MGI ID: MGI:3833399
• Synonyms: al
• Gene: Plcg2 Location: Chr8:118225030-118361881 bp, + strand Genetic Position: Chr8, 64.26 cM
• Alliance: Plcg2^al page

Mutation origin

• Strain of Origin: 129S/SvEv and C57BL/6J

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: It is a single A-to-G substitution located in exon 2 that resulted in a translational stop at amino acid 54 in the N-terminal pleckstrin homology domain of the gene. Absence of protein product was confirmed by Western blot analysis of newborn heart tissue lysates in homozygous mice. (J:143529)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcg2 Mutation: 74 strains or lines available

References

• Original: J:143529 Ichise H, et al., Phospholipase C{gamma}2 is necessary for separation of blood and lymphatic vasculature in mice. Development. 2009 Jan;136(2):191-5
• All: 1 reference(s)