Cdk6^tm1Phin
Targeted Allele Detail

Summary

• Symbol: Cdk6^tm1Phin
• Name: cyclin dependent kinase 6; targeted mutation 1, Philip Hinds
• MGI ID: MGI:3833563
• Synonyms: Cdk6-LSL
• Gene: Cdk6 Location: Chr5:3391485-3581008 bp, + strand Genetic Position: Chr5, 2.04 cM, cytoband A2-A3
• Alliance: Cdk6^tm1Phin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144975
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed STOP cassette flanked by splice acceptor sites was inserted downstream of exon 1. Presence of the STOP cassette prevents expression of the gene as confirmed by western blot analysis on thymocyte extracts. (J:144975)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdk6 Mutation: 40 strains or lines available

References

• Original: J:144975 Hu MG, et al., A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis. Cancer Res. 2009 Feb 1;69(3):810-8
• All: 3 reference(s)