Il17f^tm1Awai
Targeted Allele Detail

Summary

• Symbol: Il17f^tm1Awai
• Name: interleukin 17F; targeted mutation 1, Ari Waisman
• MGI ID: MGI:3833572
• Synonyms: IL-17f^-
• Gene: Il17f Location: Chr1:20847370-20855498 bp, - strand Genetic Position: Chr1, 6.49 cM
• Alliance: Il17f^tm1Awai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144710
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6)F1

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A cassette containing a lacZ reporter gene and a floxed neomycin cassette replaced parts of exon 2 and 3 of the gene locus. Gene inactivation was confirmed by a lack of protein detectable by ELISA on the supernatant of Th17 polarized splenocytes. (J:144710)

Gene-targeting strategy for the generation of the Il17f^tm1Awai allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il17f Mutation: 28 strains or lines available

References

• Original: J:144710 Haak S, et al., IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest. 2009 Jan;119(1):61-9
• All: 4 reference(s)