Draxin^tm1Htnk
Targeted Allele Detail

Summary

• Symbol: Draxin^tm1Htnk
• Name: dorsal inhibitory axon guidance protein; targeted mutation 1, Hideaki Tanaka
• MGI ID: MGI:3833678
• Synonyms: Draxin^-
• Gene: Draxin Location: Chr4:148182894-148215155 bp, - strand Genetic Position: Chr4, 78.67 cM, cytoband E1
• Alliance: Draxin^tm1Htnk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:144923
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ cassette and a floxed neomycin cassette replaced exon 2 downstream of the ATG start site. Gene inactivation was confirmed in homozygotes by a lack of protein detected by immunohistochemistry on traverse sections of E10.5 spinal cord. LacZ expression was detected in heterozygote embryonic brains. (J:144923)

Expression

In Mice Carrying this Mutation:	43 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Draxin Mutation: 16 strains or lines available

References

• Original: J:144923 Islam SM, et al., Draxin, a repulsive guidance protein for spinal cord and forebrain commissures. Science. 2009 Jan 16;323(5912):388-93
• All: 10 reference(s)