Aox4^tm1Enga
Targeted Allele Detail

Summary

• Symbol: Aox4^tm1Enga
• Name: aldehyde oxidase 4; targeted mutation 1, Enrico Garattini
• MGI ID: MGI:3833684
• Synonyms: Aoh2^-
• Gene: Aox4 Location: Chr1:58249556-58307756 bp, + strand Genetic Position: Chr1, 28.97 cM
• Alliance: Aox4^tm1Enga page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:145029
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 22 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on extracts from the skin, Haderian glands, and liver. (J:145029)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aox4 Mutation: 79 strains or lines available

References

• Original: J:145029 Terao M, et al., Role of the molybdoflavoenzyme aldehyde oxidase homolog 2 in the biosynthesis of retinoic acid: generation and characterization of a knockout mouse. Mol Cell Biol. 2009 Jan;29(2):357-77
• All: 2 reference(s)